Welcome, , 2005
 

Table of Contents of Research Papers, Publications and Patents on Pollen Burst Ingredients
1.  GliSODin® -SOD
     (Superoxide Dismutase)

2. 
Secalate™ - Pollen Extracts
     (Secale Cereale)

3. 
Progallate™ Green Tea
     Extracts (epigallocatechin-
     3-gallate)


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SCIENCE ODDS AND ENDS

TIME Magazine Article on INFLAMMATION: In the February 24th, 2004 issue of TIME Magazine, the feature article is all about INFLAMMATION! (Click here to read the Time article “The Secret Killer”)

It has been discovered that inflammation is associated to many diseases such as MS, Lupus, Parkinson’s, Alzheimer’s, CANCER, Heart Disease, DIABETES, Arthritis and even such simple things as dental hygiene.

PubMed.gov : National Library of Medicine PubMed.gov : National Library of Medicine (Click here to search PubMed.gov in a new window) Then follow the instructions below to search this data base for independent, impartial, 3rd-party information! Put the terms below into the Search box and SEE THE EXPLOSION of independent, impartial, 3rd-party REFERENCES!

1)  Superoxide Dismutase (27,393)
2)  EGCG (786)
3) 
Glucuronic acid lactone (223)
4)  Green tea extracts (444) 
5)  Glucuronolactone (124)
6)  Epigallocatechin-3-gallate (743)
7)  Flower Pollen Extract (962)
8)  SOD (11,119)

Antioxidants can play a significant role in reducing muscle soreness and improving recovery time for athletes. Here are just two articles that show how using antioxidants like Pollen Burst can play a significant role recovery, reduction of muscle damage and overall physical activity and health.  Click to view each article. (article 1 and article 2)


Here are just a few of the thousands of research studies and publications about the Pollen Burst ingredients. Most of these references open to complete publications. So follow the links that interest you. This is a lot to absorb, so take your time.
There is a lot of information on this page. However, we are adding to this Research information almost every week. Come back on Monday or Friday and see what is new. Like the brand new GliSODin research monograph. Just click HERE.

Patents, Articles and Clinical Studies on  SOD, SOD/Gliadin (GliSODin®).

1. THE FIRST ORALLY EFFECTIVE VEGETARIAN FORM OF SUPEROXYDE DISMUTASE (SOD) October 9 2004 : THE SUPEROXIDE DISMUTASE/GLIADIN ("GliSODin") PRODUCT, Bernard DUGAS, CSO, PhD
A Health Promoting and Anti-Aging Nutraceutical ProductImmunity, Oxidative stress & Pharmacology Immunity. Article covers: Oxidative Stress,
Pharmacology,  References and A Health Promoting and Anti-Aging Nutraceutical Product (click Here for full text of article).

2. From Enzyme University.com, Enzyme Descriptions
SOD (Superoxide dismutase)/gliadin,  Information provided by National Enzyme Company, Apr 27, 2004, 17:24
SOD (Superoxide dismutase)/gliadin catalyzes the destruction of superoxide free radicals. SOD/gliadin is a uniquely vegetarian source of highly absorbable SOD that works synergistically with endogenous SOD to prevent the oxidative effects of superoxide. Evidence suggests that antioxidant enzymes, such as SOD/gliadin, can be useful supplements for anti-oxidant support, anti-inflammatory support, immune support, and cardiovascular support.

3. United States Patent 6,045,809, Postaire , et al. April 4, 2000
Pharmaceutical compositions containing a superoxide dismutase
Abstract

Novel pharmaceutical compositions that are particularly suitable for oral administration of superoxide dismutases (SODs) and that have good bioavailability and therapeutic efficacy. These compositions are made up of a combination of a superoxide dismutase and at least one lipids or proteins. The lipids are exemplified by ceramides, and the proteins are exemplified by prolamines or polymer films based on such prolamines. A pharmaceutically acceptable vehicle can also be included in the composition. (click Here for full text of patent)

4. United States Patent 6,190,658, McCord , et al. February 20, 2001 Genetically modified manganese superoxide dismutase for treating oxidative damage
Abstract
This invention discloses a genetically modified manganese superoxide dismutase nucleic acid molecule and protein. Also disclosed are recombinant molecules, recombinant cells, therapeutic compositions and methods of using the modified manganese superoxide dismutase to treat oxidative damage.
(click Here for full text of patent)

5. United States Patent 6,030,611, Gorecki , et al. February 29, 2000
Therapeutic SOD compositions and uses thereof
Abstract
Improved methods for production of recombinant human superoxide dismutase and analogs thereof have been developed. Such superoxide dismutase or analogs may be used to catalyze the reduction of superoxide radicals thereby preventing or treating injury resulting from the presence of such superoxide radicals.
(click Here for full text of patent)

6. United States Patent 6,503,506, Germano January 7, 2003
Nutrient therapy for immuno-compromised patients
Abstract
A nutritional supplement is taught for treating chronic debilitating diseases such as HIV/AIDS to overcome conditions of oxidative stress, decreased lean muscle mass, decreased energy production (mitochondrial failure) and support immune function. It comprises orally administrable superoxide dismutase (SOD), preferably SOD/GLIADIN, in combination with other antioxidant/immune support components (Beta Glucans, Nucleotides, Fruit Polyphenols); High Immunoglobin Whey; (undenatured whey), Ornithine alpha ketoglutarate (OKG), Branched Chain Amino Acids and Glutamine to reduce loss of lean muscle mass; and Coenzyme Q 10, D-Ribose and L-Carnitine to provide energy support (decrease mitochondrial failure).

7. Influence of an Orally Effective SOD on Hyperbaric Oxygen-related Cell Damage
CLAUS M. MUTHa,b,*, YVONNE GLENZa, MICHAEL KLAUSa, PETER RADERMACHERa, GU¨ NTER SPEITb and XAVIER LEVERV (click Here for full text of article in PDF format)

8. Influence of an Orally Effective Superoxide Dismutase (GliSODin) on Strenuous Exercise-Induced Changes of Blood Antioxidant Enzymes and Plasma Lactate. Y Hong, S Hong, Y.H. Chang and S. H. Cho. \Exhausting exercise is responsible for a significant increase in blood TAS, SOD, GR and Lac....GliSODin induces a significant change in oxidative statue and a significant decrease in exercise induced lactate release. (click Here for full text of article in PDF format)

9. GliSODin Improves Quality of Life for Women. In a study of 100 women, 87% niticed an overall improvement in the quality of their skin and 73% an improvement in the quality of their life. (click Here for full text of article in PDF format)


 

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Articles, References, Clinical Studies and Scientific Papers on the
Therapeutic Properties of Pollen Extracts
(Click on the Underlined text for complete article)

1. Flower Pollen Extract and its Effect as an Anti-Inflammatory (PDF)
Platelet Aggregation Under the Influence of pollen
2. Flower Pollen Extract and its Effect on Diabetes (PDF)
Platelet Aggregation Under the Influence of pollen
3. Flower Pollen Extract and its Effects on Women's Health (PDF)
Clear cell adenocarcinoma of the female urethra showing strong immuno-staining for prostate-specific antigen
4. Flower Pollen Extract and its Effect on Common Cold
Prospect On Pollen
Pollen as a Prophylactic Against the Common Cold
5. Flower Pollen Extract and its Effect on Alcoholism
Treatment of Chronic Alcoholics
6. Flower Pollen Extract and its Effects on Eating Disorders
A New Approach to the Natural Treatment of Protein Malnutrition; Result of' a Double-Blind Clinical Trial

7. Additional SOD Publications (click here)

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7. Flower Pollen Extract and its Effect on Geriatrics
Opinion of Pollen Preparations
8. Flower Pollen Extract and its Effect on Allergies
Results of an open clinical trial with (Pollen Extract) in patients with Pollinosis
Study of Tolerance of Sthenorex in Patients with Pollen Allergy
Assessment of Sensitizing Potential
Double-blind, comparative, clinical study and placebo in patients with hay fever
9. Flower Pollen Extract - Effect on Fertility
Effects of Pollen Extract EA-10, P5 on Chronic Prostatitis or Infertility with Chronic Prostatitis (PDF)
Effect of pollen-extract on the Sex-hormone-induced Nonbacterial Prostatitis in Rats
Efficacy of administration for infertile males associated with asymptomatic pyospermia
10. Flower Pollen Extract and its effects on Urinary / Bladder / Smooth Muscles
Effects of Pollen Extract Components, Diamines & Derivatives of Feruloylputrescine on Isolated Bladder and Urethral Smooth Muscles of Mice (PDF)
A Critical Review of Flower pollen extract for Symptomatic Relief Of Lower Urinary Tract Symptoms (LUTS) in Men
A Critical Review for Symptomatic Relief Of Lower Urinary Tract Symptoms (LUTS) in Men
Effect of pollen-extract on the Function of Urinary Bladder in Conscious Rats
A. Nagashima, M. Ishii, M. Yoshinaga, E. Higaki
11. Flower Pollen Extract and its effects on the liver:
The effect of the pollen extracts on the liver, lungs, and stomach of rats intoxicated with ammonium fluoride M. Humiczewska, U. Hermach, A. Put
Effect of pollen extracts on selected biochemical parameters of liver in the course of chronic ammonium fluoride poisoning in rats Z. Mysliwiec
Experimental evaluation of the effect of pollen extract on the course of paracetamol poisoning S. Juzwiak
The effect of pollen on the changes in the liver of laboratory rats evoked by ethionine, carbon tetrachloride, allyl alcohol and galactosamine L. Samochowiec, J. Wojcicki
The effect on galactosamine- induced hepatic injury in rat J. Wojcicki, L. Samochowiec, A. Hinek
The protective effect of pollen extracts against allyl alcohol damage of the liver J. Wojcicki, A. Hinek, L. Samochowiec
12.Flower Pollen Extract and its effects on cancer:
The Secalosides Novel Tumor Cell Growth Inhibitory Glycosides from a Pollen Extract (PDF)
Clear cell adenocarcinoma of the female urethra showing strong immunostaining for prostate-specific antigen (PDF)
Antitumour potential of pollen extract on Lewis lung carcinoma implanted intraperitoneally in syngeneic mice
Cyclic hydroxamic acid inhibitors of prostate cancer cell growth: selectivity and structure activity relationships K.P. Roberts, R.A. Iyer, G. Prasad, L.T. Liu, R.E. Lind, P.E. Hanna
Isolation and characterization of a cyclic hydroxamic acid from a pollen extract, which inhibits cancerous cell growth in vitro X. Zhang, F.K. Habib, M. Ross, U. Burger, A. Lewenstein, K. Rose, J.C. Jacton
In vitro evaluation of the pollen extract, in the regulation of prostate cell growth F.K. Habib, M. Ross, A.C. Buck, L. Ebeling, A. Lewenstein
13. Flower Pollen Extract and its effects on smooth muscle:
Effects of Pollen Extract on the Isolated Bladder Smooth Muscles and the Intravesical Pressure Onodera S, Yoshinaga M, Takenaga K, Toyoshima A, Uchiyama T
Inhibitory Effect and Synergism of Pollen Extract on the Urethral Smooth Muscle and Diaphragm of the Rat Nakase K, Takenaga K, Hamanaka T, Kimura M
Immunomodulator effects of  Flower Pollen Extract:
General immunological properties of fat-soluble and water-soluble pollen extracts Samochowiec, L., Wójcicki, J. and Gieldanowski, J.
14. Flower Pollen Extract - other effects:
Clinical Trial of the Proprietary Product “C.P.”* (Amplamil)
The Use of Extract of Organic Pollen, to Stabilize Body Weight and to Increase Resistance Toward Infections
Effect of pollen extract on the course of poisoning with organic solvents M. Ceglecka
The role in cadmium effect on the absorption processes in rat small intestine M. Howaniec, A. Mekail, G. Chroszcz
Influence of a high fat diet on the rabbit's heart muscle
Antioxidant properties of pollen:
Study on the antioxidant properties of pollen extracts J. Wojcicki, L. Samochowiec, D. Kadlubowska, A. Kownacka
15. Flower Pollen Extract and its effects on atherosclerosis:
Effect of pollen extract on the development of experimental atherosclerosis in rabbits J. Wojcicki, L. Samochowiec, B. Bartlomowicz, A. Hinek, M. Jaworska, B. Gawronska-Szklarz
16. Flower pollen effects on athletes:
Effects of Pollen Extract Upon Adolescent Swimmers
Metabolic adaptation of muscles to exercise, vibration and raised temperature under the influence pollen extracts T.J. Sawicka, P. Laszczyca, B. Smylla, Z. Jethon
17. Flower Pollen Extract - GBX/T60:
Pollen extract - Indications and Uses

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Clinical Studies of the Therapeutic Value of Green Tea Extracts
(Click on the Underlined text for complete article)

1. Green Tea and Blood Pressure / Hypertension Research
A study published in the July 2004 issue of the Archives of Internal Medicine found that among persons consuming tea regularly for at least one year, the risk of developing high blood pressure was 46% lower among those who drank ˝ cup to 2 ˝ cups per day, and 65% less among those consuming more than 2 ˝ cups per day. Yang YC, Lu FH, Wu JS, Wu CH, Chang CJ. The protective effect of habitual tea consumption on hypertension. Arch Intern Med. 2004 Jul 26;164(14):1534-40.

In another study, this one of rats bred not only have high blood pressure but also to be prone to strokes, those rats given green tea had significantly lower systolic and diastolic blood pressure compared to controls, who received plain water. The animals in this study, which was published in the January 2004 issue of the Journal of Nutrition, consumed the human equivalent of 1 liter (1.1 quarts or a little more than 4 cups) of green tea per day. Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr. 2004 Jan;134(1):38-42

Green Tea Research - Protects the Liver from Alcohol and Other Harmful Chemicals
Alcohol metabolism results in the production of damaging free radicals that can overwhelm the liver's supply of antioxidants, resulting in liver injury. In a study published in the January 2004 issue of Alcohol in which rats were chronically intoxicated with alcohol for 4 weeks, green tea prevented damage to their livers. Ostrowska J, Luczaj W, Kasacka I, Rozanski A, Skrzydlewska E. Green tea protects against ethanol-induced lipid peroxidation in rat organs. Alcohol. 2004 Jan;32(1):25-32.

2. Green Tea and Allergy Reduction Research
In a study printed in the Oct. 2002 issue of the Journal of Agricultural and Food Chemistry, researchers in Japan identified a compound in green tea (ECGC) that may block a key cell receptor involved in producing an allergic response in humans. American Chemical Society: http://center.acs.org/

3. Green Tea and its Effects in Arthritis Research
Antioxidants in green tea may reduce the severity of rheumatoid arthritis, according to a study from Case Western Reserve University's School of Medicine published in the April 13 issue of the Proceedings of the National Academy of Sciences. http://www.cwru.edu

Independent, published articles have been completed showing the positive benefits of Green Tea in the area arthritis. Below are a handful of articles conducted on the effects of the components found within Green Tea:

Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes.Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM.Department of Orthopedics, Case Western Reserve University, Cleveland, OH 44106-4946, USA. [Study #6]

Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB.
Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM. Case Western Reserve University, Cleveland, Ohio 44106-4946, USA.
[Study #7]

Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro.
Adcocks C, Collin P, Buttle DJ.
Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK.
[Study #8]

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